Lentigines are harmless and treatment is often required only from the cosmetic point of view. Mild cases of Lentigines are treated using skin lightening agents, antioxidants and sun protection. However in case of chronic and relapsing types, a combination approach involving external applications and oral medication is used. The combination approach helps to lighten the patch from the surface as well as reduce the activity of the melanocytes internally.
It is important to distinguish the harmless Lentigines from early malignant melanoma. A biopsy should be considered if a lesion shows irregular border, changes in color or thickness.